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Tapentadol is a centrally operating opioid analgesic that is prescribed to treat moderate to extreme treatment of pain. It’s renowned due to its dual mechanisms of action and functions as a mu-opioid receptor antagonist and a norepinephrine-reuptake inhibit (NRI). Its dual mechanism of action makes it efficient for treating non-nociceptive (physical injuries pain) and nerve-related (nerve-damaged pain) pain.